MagicMind™ Focus Enhancing Energy Shot - Box of 15 Bottles

The ‘Energy’ Drink that will get you thinking!

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Product Features

MagicMind™ is a focus enhancing beverage developed with a unique selection of the South African plant Sceletium that is rich in mesembrenone, and low in mesembrine developed into a proprietary, standardized extract. This natural plant extracts combined with our proprietary blend of ingredients is designed to improving Cognitive Function, Stress Reduction & Mood Enhancement providing confidence and focus. We have partnered up with Zembrin® to bring the world a new way to get energized for life.

Product Description

Highlights of Magic Mind™

  • Clinically evaluated for safety & efficacy
  • Supported by 300 years of indigenous use
  • Patented
  • Standardized & vertically integrated from seed to extract
  • Self-affirmed GRAS (FDA: General Recognized As Safe)
  • Ecologically & socially responsible
  • No withdrawal effects

Origins of Sceletium Use For Mood, Stress, Cognitive Health:

*Gericke, N. Clinical application of selected South African medicinal plants. Australian Journal of Medical Herbalism 2001 (13) 3–17.

Important note: All studies, safety data, claims, patents, bioprospecting permits and export permits are related to Zembrin’s proprietary standardized extract and is not applicable to other forms of Sceletium.

Product Story

With more than 300 years of indigenous use and numerous studies, Magic Mind’s Zembrin® has been shown to be safe and effective. Here are a few examples:

Safety has been confirmed by a full array of safety & toxicity evaluations…

I. CLINICAL SAFETY STUDY:

A RCT evaluation of 25mg of Zembrin® in 36 healthy adult volunteers over a 12 week period* Zembrin® was safe and well tolerated

•IN VIVO: No chronic toxicity 90 day study at 70 mg/kg per day
•IN VIVO: No acute toxicity at 5000 mg/kg
•IN VITRO: No toxicity; Ames test, Micronucleus, hERG

*Nell et al (2012) A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial of Extract Sceletium tortuosum (Zembrin) in Healthy Adults. J Alt Compl Medicine 18:1-7

II. PUBLISHED PHASE 1 SAFETY STUDY

Clinical evaluation for 12 weeks demonstrates safety in humans
Study design:

• Objective: To evaluate safety and tolerability of Zembrin at two levels of intake (8 mg/d or 25 mg/d)
• Randomized, double-blind, placebo controlled clinical trial
• 37 healthy volunteers, age 18-55 years old

Magic Mind’s Zembrin® shown to be well tolerated

• No differences among the 3 treatment groups in vital signs, ECG, body weight and physical exam between baseline and end of study.
• Unsolicited positive effects on wellbeing were noted by some participants taking Zembrin, including improved coping with stress and sleep.

Nell et al. 2012 A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial of Extract Sceletium tortuosum (Zembrin) in Healthy Adults. J Altern Compl Med 18:1-7.

III. EFFECTS ON COGNITIVE FUNCTION

Clinical Trial Details – Chiu et al

Study site:

1. University of Western Ontario, Canada
2. PI: Dr. Simon Chiu
3. Clinical Investigator: Dr. Michael Woodbury

Double-Blind, Pacebo-Controlled Crossover Study

•21 volunteers (male and female), mean age 54.6 + 6 years
•25 mg of Zembrin® or placebo daily
•Healthy Population: No DSM IV-R cognitive or mood disorders

Chiu, et al (submitted)

IV. COGNITIVE FUNCTION

Significantly Improved Key Cognitive Domains…

V. COGNITIVE FLEXIBILITY

1. Ability to shift attention between two or more tasks and the ability to adapt to rapidly changing directions and intelligently utilize the information.
2. Necessary for decision-making, impulse control and strategy formation.

CNS VitalSign® has been used for testing neurocognitive function by over 5000 clinicians in 52 countries

VI. EXECUTIVE FUNCTION

•Refers to exercising initiative, proper judgment, discipline and the ability to operate in favor of an abstract reward.
•Spontaneous ability to take action and goal-directed behavior.

CNS VitalSign® has been used for testing neurocognitive function by over 5000 clinicians in 52 countries

VII. STRESS REDUCTION & MOOD ENHANCEMENT

HAM-D SCORE

‘Gold-Standard’ to assess severity of depression and response to therapy in clinical research

Results: Reduction of stress and improvement of mood manifested through:

1. Statistically significant improved quality of sleep
2. Less fatigue
3. Enhanced work performance
4. Enhanced interest in daily activities
5. Less irritability, worry and insecurity

Chiu, et al (2013)

VIII. STRESS MANAGEMENT

Functional MRI (fMRI) Evaluation – Terburg et al, 2014

Study Site:

1. University of Cape Town, South Africa
2. Investigators: Drs. David Terburg, Dan Stein and Jack van Honk

Method: Double Blind, Palcebo-Controlled Crossover Study

•16 volunteers (male and female), 18–21 years
•25 mg of Zembrin® or placebo – single dose
•Healthy Population: healthy undergraduate students, no history of neurological or psychopathology

Crossover Clinical Study Design

IX. PARAMETERS EVALUATED

Activation and Response of the brain to threat/stress via:

•Perpetual-load test
•Emotion-masking task

Terburg D et al. 2013 Acute Effects of Sceletium tortuosum (Zembrin), a Dual 5-HT Reuptake and PDE4 Inhibitor, in the Human Amygdala and its Connection to the Hypothalamus. Neuropsychopharmacology 1-9

fMRI Study Results Show Reduced Stress Response!

ZEMBRIN® MAY HELP IN THE MANAGEMENT OF STRESS IN EVERYDAY LIFE!

•A single dose of Zembrin® attenuates reactivity within the part of the brain (amygdala) that responds to threat/stress

Working Hypotheses:

DUAL EFFECT OF 2 ACTIVITIES (SSRI REUPTAKE AND PDE-4 INHIBITION) WORKING SYNERGISTICALLY:

1) PDE-4 INHIBITION Increases intracellular cAMP
cAMP / cGMP regulation critical in memory-related processes Cognitive Function
Neuroprotection
Depression
Alzheimer’s
Inflammation

2) INHIBITS 5-HT REUPTAKE
•Anxiolytic effect of SSRIs
•Stress negatively affects cognitive function

Product Reviews

Overall Customer Rating:
5 out of 5
Nellie R.
Age: 35
Gender: Female
Would you recommend this to your friends? Heck Yes
Date Reviewed: April 25, 2017
I love this Magic Stuff
This MagicMind stuff is off the charts - feel great all day, clear-headed...awesome stuff...send me a truckload guys!!
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Make Life Magical!